• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    This invention relates to biotechnology and relates to the preparation of substances that are immunosuppressants of cellular immunity. For the preparation of substances 55185RP and 59451RP, which are cyclodepsipeptides, the strain STREPTOMYCES SP is used. CBS N 162.86 isolated from a soil sample. The strain is cultured in a nutrient medium containing sources of nitrogen, carbon, and mineral salts under deep aerobic conditions. The culture fluid is separated, the mycelium is separated and extracted with an organic solvent. The extract obtained is separated by chromatography and the desired products are purified. 1 tab.
    公开号:SU1535383A3
    申请号:SU874202611
    申请日:1987-05-21
    公开日:1990-01-07
    发明作者:Декамп Морис；Флош Франсуа；Жюнг Жерар；Марграфф Родольф
    申请人:Рон-Пуленк Санте (Фирма)；
    IPC主号:
    专利说明:

    Agaric Melanin Vax-manna
    Difco Nutritious Broth
    Is bad
    Average
    Agazirovanna
    with casein Good
    Tyrosine agazirovanna
    Yellowish light None None
    Flake white cotton culture
    Yellowish white to brownish yellow plentiful and folded
    Yellowish white folded
     and
    Whitish, very weak development
     and
    Whitish, very weak development
    Average
    Good
    Whitish
    Yellowish segmented well developed
    Missing
    White abundant
    37% skim milk
    Compiled by G. Smirnov Editor V. Petrash Tehred M. Khodanych Corrector S. Cherni
    Order 58
    Circulation 467
    VNIIPI State Committee for Inventions and Discoveries at the State Committee on Science and Technology of the USSR 113035, Moscow, Zh-35, Raushsk nab. 4/5
    Production and publishing plant Patent, Uzhgorod, st. Gagarin, 101
    Segmental brownish quite well developed.
    Subscription
    权利要求:
    Claims (1)
    [1]
    Claim
    A method of obtaining biologically Ak, 55185 tive substances RP and RP 59451, having immunosuppressive action, of the general formula wherein X-Cl (substance 55185 RP) or H (Compound 59451 RP), comprising: r that strain Streptomyces sp. CBS No. 162.86 is cultivated in a nutrient medium containing sources of nitrogen, carbon and mineral salts, under deep aerobic conditions, followed by separation of the mycelium, extraction with an organic solvent, chromatographic separation and purification of the target products.
    I I
    ---------------- - --------------- 4Cultural Power Vegetative Air system Soluble Wednesday development mycelium or topic (consisting of pigmenttowards from environment bathing aerial mice lia and sporulation) 1 2 3 4 5 •_ __________JI S P Good Yellowish white pleated Is absent ____ -Is absent IS P 2 Brown beige Whitish with pleated trace level ny debatable 1 S P }Average White, grayish Is absent I S R. Highly Beige yellow Numerousgood cotton ny folded Beige pink I S Pj Weak Beige, grayishfolded Is absent - I s Enough Whitish abundance - ”-good foldedI S 1 ’ Also Pleated whiteEasy to growyellowishbrownish red pigment Agarized Melanin Wax manna Bad Yellowish light Is absent Is absent Difco Nitrate Nutrient Broth Average Flaky white-cotton culture - - Agate - n - with casein Good Yellowish white to brownish yellow profuse and pleated Tyrosine Aggravated _ m Yellowish b Whitish, _and_folded very weak development
    Culture on a pure 12%
    gelatin Average Whitish Is absent 28 ° C Good Yellowish, segmented, good White low mobility
    sho developed
    thirteen 1535383 14Table continuation 11 1 3 4 S The removed skim milk 37 C _ and - The segmented brownish is well developed. Is absent
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    同族专利:
    公开号 | 公开日
    ZA873638B|1987-11-17|
    DK258487A|1987-11-23|
    FI872235A0|1987-05-21|
    PT84933A|1987-06-01|
    PT84933B|1989-07-20|
    FI872235A|1987-11-23|
    FR2599039A1|1987-11-27|
    DK258487D0|1987-05-21|
    EP0246975A1|1987-11-25|
    NO872130L|1987-11-23|
    AU592186B2|1990-01-04|
    US4810692A|1989-03-07|
    AU7324087A|1987-11-26|
    FR2599039B1|1988-08-05|
    KR870011153A|1987-12-21|
    JPS6354395A|1988-03-08|
    NO872130D0|1987-05-21|
    NZ220379A|1989-02-24|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US4355112A|1977-06-06|1982-10-19|Sanraku-Ocean Co., Ltd.|Streptomyces culture|CA2059380A1|1991-01-24|1992-07-25|Yiu-Kuen T. Lam|Endothelin receptor antagonists isolated from microbispora|
    GB2266890A|1992-04-17|1993-11-17|Merck & Co Inc|Antihypertensive compounds by dechlorination of cyclic depsipeptides|
    US5240910A|1992-04-17|1993-08-31|Merck & Co., Inc.|Antihypertensive compounds produced by fermentation|
    AU2002322720B2|2001-07-25|2008-11-13|Raptor Pharmaceutical Inc.|Compositions and methods for modulating blood-brain barrier transport|
    WO2006115509A2|2004-06-24|2006-11-02|Novartis Vaccines And Diagnostics Inc.|Small molecule immunopotentiators and assays for their detection|
    JP2008539047A|2005-04-28|2008-11-13|プロテウスバイオメディカルインコーポレイテッド|Pharma Informatics System|
    WO2008036682A2|2006-09-18|2008-03-27|Raptor Pharmaceutical Inc.|Treatment of liver disorders by administration of receptor-associated protein -conjugates|
    US20100022568A1|2006-04-13|2010-01-28|Actelion Pharmaceeuticals Ltd.|Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis|
    US20120077778A1|2010-09-29|2012-03-29|Andrea Bourdelais|Ladder-Frame Polyether Conjugates|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    FR8607269A|FR2599039B1|1986-05-22|1986-05-22|NEW IMMUNO-SUPPRESSIVE SUBSTANCE, ITS PREPARATION BY CULTURE OF STREPTOMYCES SP.AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT|
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